Penetrex (enoxacin) Disease Interactions
There are 2 disease interactions with Penetrex (enoxacin):
Quinolones (Includes Penetrex) ↔ Myasthenia Gravis
Severe Potential Hazard, Moderate plausibility
Applies to: Myasthenia Gravis
Fluoroquinolones have neuromuscular blocking activity and may exacerbate muscle weakness in persons with myasthenia gravis. Postmarketing serious adverse events, including deaths and requirement for ventilatory support, have been associated with fluoroquinolones use in persons with myasthenia gravis. Fluoroquinolones should be avoided in patients with history of myasthenia gravis.
Quinolones (Includes Penetrex) ↔ Tendonitis
Severe Potential Hazard, Moderate plausibility
Applies to: Tendonitis
Tendonitis and ruptures of the shoulder, hand, and Achilles tendons have been reported in patients receiving quinolones, both during and after treatment. Therapy with quinolones should be administered cautiously in patients with preexisting tendonitis, since it may delay the recognition or confound the diagnosis of a quinolone-induced musculoskeletal effect. It is recommended to discontinue these agents if, at any time during therapy, pain, inflammation or rupture of a tendon develop and institute appropriate therapy.
- "Product Information. Penetrex (enoxacin)." Rhone-Poulenc Rorer, Collegeville, PA.
- "Product Information. Trovan (trovafloxacin)." Pfizer US Pharmaceuticals, New York, NY.
- Donck JB, Segaert MF, Vanrenterghem YF "Fluoroquinolones and achilles tendinopathy in renal transplant recipients." Transplantation 58 (1994): 736-7
- "Product Information. Zagam (sparfloxacin)." Rhone-Poulenc Rorer, Collegeville, PA.
- Schacht P, Arcieri G, Hullmann R "Safety of oral ciprofloxacin. An update based on clinical trial results." Am J Med 87 (1989): s98-102
- "Product Information. Factive (gemifloxacin)." GeneSoft Inc, San Francisco, CA.
- Casparian JM, Luchi M, Moffat RE, Hinthorn D "Quinolones and tendon ruptures." South Med J 93 (2000): 392-6
- Carrasco JM, Garcia B, Andujar C, Garrote F, de Juana P, Bermejo T "Tendinitis associated with ciprofloxacin." Ann Pharmacother 31 (1997): 120
- "Product Information. Floxin (ofloxacin)." Ortho Pharmaceutical Corporation, Raritan, NJ.
- "Product Information. Cipro (ciprofloxacin)." Bayer, West Haven, CT.
- "Product Information. Cinobac (cinoxacin)." Oclassen Pharmaceuticals Inc, San Rafael, CA.
- "Product Information. Levaquin (levofloxacin)." Ortho Pharmaceutical Corporation, Raritan, NJ.
- "Product Information. Noroxin (norfloxacin)." Merck & Co, Inc, West Point, PA.
- Zabraniecki L, Negrier I, Vergne P, Arnaud M, Bonnet C, Bertin P, Treves R "Fluoroquinolone induced tendinopathy: report of 6 cases." J Rheumatol 23 (1996): 516-20
- "Product Information. NegGram (nalidixic acid)." Sanofi Winthrop Pharmaceuticals, New York, NY.
- "Product Information. Tequin (gatifloxacin)" Bristol-Myers Squibb, Princeton, NJ.
- "Product Information. Maxaquin (lomefloxacin)." Searle, Skokie, IL.
- "Product Information. Avelox (moxifloxacin)" Bayer, West Haven, CT.
Penetrex (enoxacin) drug Interactions
There are 453 drug interactions with Penetrex (enoxacin)
Penetrex (enoxacin) alcohol/food Interactions
There are 2 alcohol/food interactions with Penetrex (enoxacin)
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.
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