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Marinol (dronabinol) Disease Interactions

There are 4 disease interactions with Marinol (dronabinol):

Moderate

Dronabinol (Includes Marinol) ↔ Seizures

Moderate Potential Hazard, Moderate plausibility

Applies to: Seizures

Seizures and seizure- like activity have been reported in patients using dronabinol. Caution is advised in patients with history of a seizure disorder, as dronabinol may lower seizure threshold. Therapy should be discontinued immediately in patients who develop seizures and medical attention should be sought immediately.

Moderate

Miscellaneous Antiemetics (Includes Marinol) ↔ Cardiac Disease

Moderate Potential Hazard, Moderate plausibility

Applies to: Cardiovascular Disease

The use of some antiemetics such as dronabinol and nabilone has been associated with occasional hypotension, possible hypertension, syncope or tachycardia. Therapy with these drugs should be administered cautiously in patients with cardiac disease.

References

  1. "Product Information. Marinol (dronabinol)." Roxane Laboratories Inc, Columbus, OH.
Moderate

Miscellaneous Antiemetics (Includes Marinol) ↔ Psychoses/Depression

Moderate Potential Hazard, High plausibility

Applies to: Depression, Psychosis

Some antiemetics such as dronabinol and nabilone may precipitate or exacerbate psychotic symptoms or anxiety, depression, hallucinations or psychosis. Therapy with these drugs should be administered cautiously in patients with a history of psychiatric disorders, emotional instability, or depression, and particularly if they are elderly. Careful psychiatric monitoring is advised.

References

  1. "Product Information. Marinol (dronabinol)." Roxane Laboratories Inc, Columbus, OH.
Moderate

Miscellaneous Antiemetics (Includes Marinol) ↔ Substance Abuse

Moderate Potential Hazard, High plausibility

Applies to: Drug Abuse/Dependence, Alcoholism

Some antiemetics as dronabinol and nabilone have a significant potential for abuse. Therapy with these drugs should be administered cautiously in patients with a history of substance abuse. It may be prudent to refrain from dispensing large quantities of dronabinol to these patients.

References

  1. "Product Information. Marinol (dronabinol)." Roxane Laboratories Inc, Columbus, OH.

Marinol (dronabinol) drug Interactions

There are 593 drug interactions with Marinol (dronabinol)

Marinol (dronabinol) alcohol/food Interactions

There is 1 alcohol/food interaction with Marinol (dronabinol)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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