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DDAVP Rhinal Tube (desmopressin) Disease Interactions

There are 2 disease interactions with DDAVP Rhinal Tube (desmopressin):

Major

Desmopressin (Includes DDAVP Rhinal Tube) ↔ renal dysfunction

Severe Potential Hazard, High plausibility. Applies to: Renal Dysfunction

The use of desmopressin is contraindicated in patients with moderate to severe renal impairment (defined as a creatinine clearance below 50 mL/min).

References

  1. Affarah HB, Mars RL, Someren A, Smith HW 3d, Heymsfield SB "Myoglobinuria and acute renal failure associated with intravenous vasopressin infusion." South Med J 77 (1984): 918-21
  2. "Product Information. Stimate (desmopressin)." Forest Pharmaceuticals, St. Louis, MO.
  3. "Product Information. DDAVP (desmopressin)." Rhone-Poulenc Rorer, Collegeville, PA.
  4. "Product Information. Pitressin (vasopressin)." Parke-Davis, Morris Plains, NJ.
View all 4 references
Major

Vasopressin/desmopressin (Includes DDAVP Rhinal Tube) ↔ fluid overload/hyponatremia

Severe Potential Hazard, High plausibility. Applies to: Fluid Retention, Seizures, Congestive Heart Failure, Migraine, Asthma, Hyponatremia

Water intoxication and hyponatremia may occur during therapy with vasopressin or desmopressin due to their antidiuretic action. Patients are most likely to experience this problem if their fluid intake is excessive or if they do not require antidiuresis, such as when they are administered these agents for their hemostatic effects. Fluid intake should be adjusted carefully to avoid overhydration, particularly in children, elderly, and patients with conditions that may be exacerbated by fluid retention, including epilepsy, migraine, asthma, and heart failure. Patients should be monitored for signs of water intoxication (e.g., listlessness, drowsiness, and headaches), which may rarely progress to seizures and coma. The use of desmopressin is contraindicated in patients with hyponatremia or a history of hyponatremia.

References

  1. "Product Information. Pitressin (vasopressin)." Parke-Davis, Morris Plains, NJ.
  2. Robson WLM, Norgaard JP, Leung AKC "Hyponatremia in patients with nocturnal enuresis treated with DDAVP." Eur J Pediatr 155 (1996): 959-62
  3. Robson WLM "Water intoxication in patients treated with desmopressin." Pharmacotherapy 16 (1996): 969-70
  4. "Product Information. Stimate (desmopressin)." Forest Pharmaceuticals, St. Louis, MO.
  5. "Product Information. DDAVP (desmopressin)." Rhone-Poulenc Rorer, Collegeville, PA.
  6. Williford SL "Water intoxication in patients treated with desmopressin - reply." Pharmacotherapy 16 (1996): 970
  7. Lin TW, Kuo YS "Acute pulmonary oedema following administration of vasopressin for control of massive GI tract haemorrhage in a major burn patient." Burns 22 (1996): 73-5
  8. Tulandi T, Beique F, Kimia M "Pulmonary edema: a complication of local injection of vasopressin at laparoscopy." Fertil Steril 66 (1996): 478-80
View all 8 references

DDAVP Rhinal Tube (desmopressin) drug interactions

There are 277 drug interactions with DDAVP Rhinal Tube (desmopressin)

DDAVP Rhinal Tube (desmopressin) alcohol/food interactions

There is 1 alcohol/food interaction with DDAVP Rhinal Tube (desmopressin)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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