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Desferal (deferoxamine) Disease Interactions

There are 4 disease interactions with Desferal (deferoxamine):

Major

Deferoxamine (Includes Desferal) ↔ Renal Dysfunction

Severe Potential Hazard, High plausibility

Applies to: Renal Dysfunction

The use of deferoxamine is contraindicated in patients with severe renal impairment or anuria. Deferoxamine chelates iron and the complexes are primarily eliminated by the kidney.

References

  1. "Product Information. Desferal (deferoxamine)." Novartis Pharmaceuticals, East Hanover, NJ.
Moderate

Deferoxamine (Includes Desferal) ↔ Auditory Dysfunction

Moderate Potential Hazard, High plausibility

Applies to: Hearing Loss

Neurotoxicity-related auditory abnormalities such as tinnitus and hearing loss including deafness have occurred after prolonged therapy or large doses of deferoxamine, or in patients with low ferritin levels. Therapy with deferoxamine should be administered cautiously in patients with hearing impairment. Hearing toxicity is usually reversible if detected early and deferoxamine discontinued.

References

  1. "Product Information. Desferal (deferoxamine)." Novartis Pharmaceuticals, East Hanover, NJ.
Moderate

Deferoxamine (Includes Desferal) ↔ Ocular Dysfunction

Moderate Potential Hazard, High plausibility

Applies to: Visual Defect/Disturbance

Deferoxamine may cause blurred vision, cataracts, decreased visual acuity, and impaired color, peripheral, and night vision. Ocular toxicities have occurred after prolonged therapy, large doses, and in patients with decreased ferritin levels. Therapy with deferoxamine should be administered cautiously in patients with or predisposed to visual defects. Periodic examination of visual acuity is recommended in patients receiving long term deferoxamine therapy. Ocular dysfunction is usually reversible if detected early and deferoxamine is withdrawn promptly.

References

  1. "Product Information. Desferal (deferoxamine)." Novartis Pharmaceuticals, East Hanover, NJ.
Moderate

Deferoxamine (Includes Desferal) ↔ Respiratory Distress Syndrome

Moderate Potential Hazard, Moderate plausibility

Applies to: Thalassemia

Acute respiratory distress syndrome has been described in patients with acute iron intoxication or thalassemia following treatment with excessively high intravenous doses of deferoxamine. Caution is recommended when using deferoxamine in these patients.

Desferal (deferoxamine) drug Interactions

There are 38 drug interactions with Desferal (deferoxamine)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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