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Cobal 1000 (cyanocobalamin) Disease Interactions

There are 3 disease interactions with Cobal 1000 (cyanocobalamin):

Major

cyano-/hydroxocobalamin (vit B12) (Includes Cobal 1000) ↔ hypokalemia

Severe Potential Hazard, High plausibility

Applies to: Hypokalemia

Hypokalemia (resulting in death) has occurred during vitamin B12 therapy as a result of increased red blood cell requirements during hematopoiesis. Clinical monitoring and correction of potassium levels prior to and during vitamin B12 therapy is necessary.

References

  1. "Product Information. Hydro-Cobex (hydroxocobalamin)." Major Pharmaceuticals Inc, Rosemont, IL.
  2. "Product Information. Nascobol (cyanocobalamin nasal)." Schwarz Pharma, Mequon, WI.
Major

cyano-/hydroxocobalamin (vit B12) (Includes Cobal 1000) ↔ optic nerve

Severe Potential Hazard, High plausibility

Applies to: Leber's Disease

The use of cyanocobalamin is contraindicated in patients with Leber's disease (hereditary optic nerve atrophy). Cyanocobalamin has induced severe and rapid optic nerve atrophy in patient's with early Leber's disease.

References

  1. "Product Information. Hydro-Cobex (hydroxocobalamin)." Major Pharmaceuticals Inc, Rosemont, IL.
  2. "Product Information. Nascobol (cyanocobalamin nasal)." Schwarz Pharma, Mequon, WI.
Moderate

cyanocobalamin (Includes Cobal 1000) ↔ renal impairment

Moderate Potential Hazard, Moderate plausibility

Applies to: Renal Dysfunction

Cyanocobalamin products contain aluminum that may be toxic and may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and other solutions which also contain aluminum. Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum greater than 4-5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Caution and monitoring are recommended.

Cobal 1000 (cyanocobalamin) drug Interactions

There are 27 drug interactions with Cobal 1000 (cyanocobalamin)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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