Clomid (clomiphene) Disease Interactions
There are 4 disease interactions with Clomid (clomiphene):
Clomiphene (Includes Clomid) ↔ abnormal uterine bleeding
Severe Potential Hazard, High plausibility. Applies to: Abnormal Uterine Bleeding
The use of clomiphene is contraindicated in patients with undiagnosed, abnormal genital bleeding. Patients should be evaluated to ensure that neoplastic lesions are not present.
Clomiphene (Includes Clomid) ↔ hepatic dysfunction
Severe Potential Hazard, High plausibility. Applies to: Liver Disease
The use of clomiphene is contraindicated in patients with liver disease or history of hepatic dysfunction.. Clomiphene undergoes enterohepatic circulation and is metabolized by the liver. The serum concentration of clomiphene may be increased and the half-life prolonged in patients with compromised hepatic function.
Clomiphene (Includes Clomid) ↔ pituitary activity
Severe Potential Hazard, High plausibility. Applies to: Pituitary Tumor, Brain/Intracranial Tumor, Thyroid Disease, Adrenal Insufficiency
The use of clomiphene is contraindicated in patients with uncontrolled thyroid or adrenal dysfunction or an organic intracranial lesion such as a pituitary tumor. Clomiphene interacts with estrogen receptors in various tissues, including the pituitary, the response of which is an increase in the release of pituitary gonadotropins.
Clomiphene (Includes Clomid) ↔ uncontrolled adrenal dysfunction
Severe Potential Hazard, High plausibility. Applies to: Adrenal Insufficiency, Hyperadrenocorticism, Adrenal Tumor, Hyperaldosteronism
The use of clomiphene is contraindicated in patients with uncontrolled adrenal function. Alterations of adrenal function can impede pregnancy. Clomiphene therapy can result in alteration in steroid synthesis and/or fluid regulation.
Clomid (clomiphene) drug interactions
There are 2 drug interactions with Clomid (clomiphene)
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- Drug class: synthetic ovulation stimulants
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
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