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Clomid (clomiphene) Disease Interactions

There are 4 disease interactions with Clomid (clomiphene):

Major

Clomiphene (Includes Clomid) ↔ abnormal uterine bleeding

Severe Potential Hazard, High plausibility. Applies to: Abnormal Uterine Bleeding

The use of clomiphene is contraindicated in patients with undiagnosed, abnormal genital bleeding. Patients should be evaluated to ensure that neoplastic lesions are not present.

Major

Clomiphene (Includes Clomid) ↔ hepatic dysfunction

Severe Potential Hazard, High plausibility. Applies to: Liver Disease

The use of clomiphene is contraindicated in patients with liver disease or history of hepatic dysfunction.. Clomiphene undergoes enterohepatic circulation and is metabolized by the liver. The serum concentration of clomiphene may be increased and the half-life prolonged in patients with compromised hepatic function.

Major

Clomiphene (Includes Clomid) ↔ pituitary activity

Severe Potential Hazard, High plausibility. Applies to: Pituitary Tumor, Brain/Intracranial Tumor, Thyroid Disease, Adrenal Insufficiency

The use of clomiphene is contraindicated in patients with uncontrolled thyroid or adrenal dysfunction or an organic intracranial lesion such as a pituitary tumor. Clomiphene interacts with estrogen receptors in various tissues, including the pituitary, the response of which is an increase in the release of pituitary gonadotropins.

Major

Clomiphene (Includes Clomid) ↔ uncontrolled adrenal dysfunction

Severe Potential Hazard, High plausibility. Applies to: Adrenal Insufficiency, Hyperadrenocorticism, Adrenal Tumor, Hyperaldosteronism

The use of clomiphene is contraindicated in patients with uncontrolled adrenal function. Alterations of adrenal function can impede pregnancy. Clomiphene therapy can result in alteration in steroid synthesis and/or fluid regulation.

Clomid (clomiphene) drug interactions

There are 2 drug interactions with Clomid (clomiphene)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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