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Relaxazone (chlorzoxazone) Disease Interactions

There is 1 disease interaction with Relaxazone (chlorzoxazone):


Chlorzoxazone (Includes Relaxazone) ↔ hepatotoxicity

Severe Potential Hazard, Low plausibility. Applies to: Liver Disease

The use of chlorzoxazone has been associated with rare cases of serious, idiosyncratic hepatocellular toxicity. Therapy with chlorzoxazone should be administered cautiously in patients with preexisting liver disease. All patients receiving chlorzoxazone should be instructed to immediately report any signs and symptoms of hepatic injury such as fever, rash, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine and jaundice, and to discontinue the drug promptly should they occur. Chlorzoxazone therapy should also be withdrawn if abnormal liver enzymes (e.g., AST, ALT, alkaline phosphatase, bilirubin) develop.


  1. "Product Information. Parafon Forte (chlorzoxazone)." Ortho McNeol Pharmceutical, Raritan, NJ.

Relaxazone (chlorzoxazone) drug interactions

There are 663 drug interactions with Relaxazone (chlorzoxazone)

Relaxazone (chlorzoxazone) alcohol/food interactions

There is 1 alcohol/food interaction with Relaxazone (chlorzoxazone)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.