Otomar HC (chloroxylenol / hydrocortisone / pramoxine otic) Disease Interactions
There are 2 disease interactions with Otomar HC (chloroxylenol / hydrocortisone / pramoxine otic):
Otic agents (Includes Otomar HC) ↔ perforated tympanic membrane
Severe Potential Hazard, High plausibility. Applies to: Perforated Tympanic Membrane, Chronic Otitis Media, Perforated Tympanic Membrane, Chronic Otitis Media, Perforated Tympanic Membrane, Chronic Otitis Media
The use of medications that are intended for the treatment of otitis externa or other conditions of the external ear canal should generally be avoided, or otherwise approached with caution, in patients with a perforated tympanic membrane due to the risk of toxicity from medication that may get into the middle ear. Caution is also advised in patients with longstanding, chronic otitis media because of the possibility of a perforated tympanic membrane in such patients.
- "Multum Information Services, Inc. Expert Review Panel"
- Behrman R, Kliegman R, Arvin A, Nelson W, eds. "Nelson Textbook of Pediatrics. 15th ed." Philadelphia, PA: W.B. Saunders Company (1996):
The use of otic preparations containing corticosteroids is contraindicated in patients with viral infections of the external canal including varicella and herpes simplex otitis externa. Corticosteroids may decrease host resistance to infectious agents, thus prolonging the course and/or exacerbating the severity of the infection while encouraging the development of new or secondary infection. Normally, corticosteroids may be administered with caution provided it is accompanied by appropriate anti-infective agents. However, otic preparations that are currently available lack effective antiviral agents.
- American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association; (1994):
More about Otomar HC (chloroxylenol / hydrocortisone / pramoxine otic)
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
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