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Urecholine (bethanechol) Disease Interactions

There are 6 disease interactions with Urecholine (bethanechol):

Major

Cholinergic agonist (Includes Urecholine) ↔ bronchospasm

Severe Potential Hazard, High plausibility. Applies to: Asthma

The use of cholinergic agonists is contraindicated in patients with uncontrolled reactive airway disease. Cholinergic agonists inhibits the hydrolysis of acetylcholine. The enhanced effect of acetylcholine produces constriction of the bronchi, increased bronchial secretions, and bronchospasm.

References

  1. "Product Information. Urecholine (bethanechol)." Merck & Co, Inc, West Point, PA.
  2. "Product Information. Salagen Tablets (pilocarpine)." Boehringer-Ingelheim, Ridgefield, CT.
Major

Cholinergic agonist (Includes Urecholine) ↔ cardiac dysfunction

Severe Potential Hazard, High plausibility. Applies to: Hypotension, Ischemic Heart Disease, Heart Block, Hypertension

The use of cholinergic agonists, such as bethanechol and pilocarpine, is contraindicated in patients with pronounced bradycardia, hypotension/hypertension, coronary artery disease or conduction disorders.

References

  1. "Product Information. Urecholine (bethanechol)." Merck & Co, Inc, West Point, PA.
  2. "Product Information. Salagen Tablets (pilocarpine)." Boehringer-Ingelheim, Ridgefield, CT.
Major

Cholinergic agonist (Includes Urecholine) ↔ GI/bladder neck obstruction

Severe Potential Hazard, High plausibility. Applies to: Colitis/Enteritis (Noninfectious), Urinary Retention, Gastrointestinal Obstruction, Peptic Ulcer

The use of cholinergic agonists is contraindicated in patients with peptic ulcers, mechanical GI obstruction, acute GI inflammatory conditions, or urinary obstruction. Cholinergic activity may result in an increase in gastric acid secretion, GI motility, and gastric contractions. In patients with urinary retention, urinary reflux may occur if the sphincter fails to relax when the bladder is contracted by cholinergic stimulation. The reflux of urine from the bladder can cause infection in the kidneys and upper urinary tract if bacteriuria is present.

References

  1. "Product Information. Salagen Tablets (pilocarpine)." Boehringer-Ingelheim, Ridgefield, CT.
  2. "Product Information. Urecholine (bethanechol)." Merck & Co, Inc, West Point, PA.
Major

Cholinergic agonist (Includes Urecholine) ↔ hyperthyroidism

Severe Potential Hazard, High plausibility. Applies to: Hyperthyroidism

The use of cholinergic agents may be contraindicated in patients with hyperthyroidism. Atrial fibrillation has occurred in hyperthyroid patients administered a cholinergic agonist.

References

  1. "Product Information. Urecholine (bethanechol)." Merck & Co, Inc, West Point, PA.
  2. "Product Information. Salagen Tablets (pilocarpine)." Boehringer-Ingelheim, Ridgefield, CT.
Major

Cholinergic agonist (Includes Urecholine) ↔ parkinsonism

Severe Potential Hazard, High plausibility. Applies to: Parkinsonism

The use of cholinergic agonists may be contraindicated in patients with parkinsonism. Cholinergic agonists directly stimulates the parasympathetic nervous system inducing acetylcholinergic effects. Symptoms of Parkinson's disease may be exacerbated.

References

  1. "Product Information. Urecholine (bethanechol)." Merck & Co, Inc, West Point, PA.
  2. "Product Information. Salagen Tablets (pilocarpine)." Boehringer-Ingelheim, Ridgefield, CT.
Major

Cholinergic agonist (Includes Urecholine) ↔ seizure disorders

Severe Potential Hazard, High plausibility. Applies to: Seizures

The use of cholinergic agonists may be contraindicated in patients with seizure disorders. Cholinomimetics have been associated with convulsions.

References

  1. "Product Information. Salagen Tablets (pilocarpine)." Boehringer-Ingelheim, Ridgefield, CT.
  2. "Product Information. Urecholine (bethanechol)." Merck & Co, Inc, West Point, PA.

Urecholine (bethanechol) drug interactions

There are 117 drug interactions with Urecholine (bethanechol)

Urecholine (bethanechol) alcohol/food interactions

There is 1 alcohol/food interaction with Urecholine (bethanechol)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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