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Coartem Disease Interactions

There are 2 disease interactions with Coartem (artemether / lumefantrine).

Major

Antimalarial agents (applies to Coartem) QT prolongation

Major Potential Hazard, Moderate plausibility. Applicable conditions: Magnesium Imbalance, Hypokalemia, Arrhythmias, Hypokalemia, Arrhythmias, Magnesium Imbalance

The use of certain antimalarial agents is contraindicated in patients with known prolongation of QT interval as these patients can develop fatal arrhythmias. These drugs should also be avoided in patients with clinical conditions known to prolong the QT interval, such as uncorrected hypokalemia or hypomagnesemia, bradycardia, and certain other cardiac conditions. Caution is advised in patients taking other medications that can prolong the QT interval.

References

  1. "Product Information. QuiNINE Sulfate (quiNINE)." Zenith Goldline Pharmaceuticals PROD
  2. "Product Information. Qualaquin (quinine)." AR Scientific Inc (2006):
  3. "Product Information. Coartem (artemether-lumefantrine)." Novartis Pharmaceuticals (2009):
Moderate

Antimalarials- hepatic/renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction, Liver Disease, Renal Dysfunction, Liver Disease

The pharmacokinetics of the antimalarial drugs artemether and lumefantrine have not been studied in patients with either hepatic or renal impairment. Additionally, the efficacy and safety of the drugs has not been studied in patients with severe hepatic and/or renal impairment. No dose adjustment is recommended for patients with renal impairment as there is no or insignificant renal excretion of lumefantrine, artemether and dihydroartemisinin (DHA), an active antimalarial metabolite of artemether. No dosage adjustment is necessary in patients with mild to moderate hepatic impairment. Caution should be exercised when administering lumefantrine and artemether to patients with severe hepatic or renal impairment. Close monitoring is recommended.

References

  1. "Product Information. Coartem (artemether-lumefantrine)." Novartis Pharmaceuticals (2009):

Coartem drug interactions

There are 367 drug interactions with Coartem (artemether / lumefantrine).

Coartem alcohol/food interactions

There is 1 alcohol/food interaction with Coartem (artemether / lumefantrine).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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