Uprima (apomorphine) Disease Interactions
There are 2 disease interactions with Uprima (apomorphine):
Dopamine agonists (Includes Uprima) ↔ hypotension
Severe Potential Hazard, Moderate plausibility. Applies to: Hypotension
Dopamine agonists may impair the systemic regulation of blood pressure, with resultant orthostatic hypotension, especially during dose escalation. Therapy with dopamine agonists should be monitored carefully in patients with Parkinson's disease since they may have an impaired ability to respond to an orthostatic challenge, and also in patients receiving antihypertensive drugs.
- "Product Information. Sinemet CR (carbidopa-levodopa)." Dupont Pharmaceuticals, Wilmington, DE.
- Iwasaki S, Hamaguchi K, Iwasaki A, Takakusagi M, Narabayashi Y "Hypotensive effect of long-term levodopa in patients with Parkinson's disease." Eur Neurol 30 (1990): 194-9
- "Product Information. Mirapex (pramipexole)." Boehringer Ingelheim, Ridgefield, CT.
- Hoehn MM "Levodopa-induced postural hypotension. Treatment with fludrocortisone." Arch Neurol 32 (1975): 50-1
- "Product Information. Dostinex (cabergoline)." Pharmacia and Upjohn, Kalamazoo, MI.
- "Product Information. Sinemet (carbidopa-levodopa)." DuPont Pharmaceuticals, Wilmington, DE.
Dopaminergic antiparkinson agents (Includes Uprima) ↔ psychosis
Severe Potential Hazard, Moderate plausibility. Applies to: Psychosis
Ordinarily, patients with major psychotic disorder should not be treated with dopaminergic antiparkinson agents, because of the risk of exacerbating psychosis. Hallucinations and psychotic-like behavior have been reported with dopaminergic medications. In addition, certain medications used to treat psychosis may exacerbate the symptoms of Parkinson's disease and may decrease the effectiveness of these drugs.
Uprima (apomorphine) drug interactions
There are 481 drug interactions with Uprima (apomorphine)
Uprima (apomorphine) alcohol/food interactions
There is 1 alcohol/food interaction with Uprima (apomorphine)
More about Uprima (apomorphine)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Drug class: dopaminergic antiparkinsonism agents
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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