Levulan Kerastick (aminolevulinic acid topical) Disease Interactions
There are 2 disease interactions with Levulan Kerastick (aminolevulinic acid topical):
Aminolevulinic Acid Topical Gel (Includes Levulan Kerastick) ↔ Porphyria
Severe Potential Hazard, Moderate plausibility
Applies to: Porphyria
Photoactivation following topical application of aminolevulinic acid topical gel occurs when aminolevulinic acid (prodrug) is metabolized to protoporphyrin IX, a photoactive compound which accumulates in the skin. Therapy with aminolevulinic acid topical gel increases photosensitivity and it may cause uncontrolled phototoxic effects. Its use in contraindicated in patients with porphyria or photodermatoses.
Aminolevulinic Acid Topical Gel (Includes Levulan Kerastick) ↔ Bleeding
Moderate Potential Hazard, Moderate plausibility
Applies to: Coagulation Defect
The use of aminolevulinic acid topical gel increases the risk of bleeding in patients with coagulation disorders. Care should be exercised during lesion preparation to avoid bleeding.
Levulan Kerastick (aminolevulinic acid topical) drug Interactions
There are 168 drug interactions with Levulan Kerastick (aminolevulinic acid topical)
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
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