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Ethyol (amifostine) Disease Interactions

There is 1 disease interaction with Ethyol (amifostine):

Major

Amifostine (Includes Ethyol) ↔ hypotension

Severe Potential Hazard, Moderate plausibility. Applies to: Ischemic Heart Disease, Cerebral Vascular Disorder, Hypotension, Congestive Heart Failure, Arrhythmias, Dehydration

Patients who are hypotensive or in state of dehydration, or those that are unable to discontinue antihypertensive treatment 24 hours prior to amifostine administration should not receive amifostine. Transient hypotensive episodes have occurred in 62% of patients receiving amifostine. Three percent of patients required discontinuation of amifostine. Therapy with amifostine should be administered cautiously in patients adversely affected by hypotensive effects such as cardiovascular conditions of arrhythmia, angina, or CHF or cerebrovascular conditions of or history of stroke or ischemic attacks. Clinical monitoring of blood pressure is necessary.

References

  1. "Product Information. Ethyol (amifostine)." Alza, Palo Alto, CA.

Ethyol (amifostine) drug interactions

There are 177 drug interactions with Ethyol (amifostine)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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