Zytiga (abiraterone) Disease Interactions
There are 2 disease interactions with Zytiga (abiraterone):
Abiraterone (Includes Zytiga) ↔ Hepatic Impairment
Severe Potential Hazard, Moderate plausibility
Applies to: Liver Disease
Postmarketing studies have associated the use of abiraterone with severe hepatic toxicity, including fulminant hepatitis, acute liver failure and deaths. Serum transaminases and bilirubin levels should be measured before starting treatment and every 2 weeks for the first three months of treatment and then monthly thereafter. Any liver test elevations should prompt more frequently monitoring. Treatment should be discontinued permanently in patients with concurrent elevations of ALT greater than 3 x ULN and total bilirubin greater than 2 x ULN. In patients with baseline moderate hepatic impairment (Child-Pugh Class B), the recommended dose should be reduced to 250 mg once daily. Abiraterone should not be used in patients with severe hepatic impairment (Child-Pugh Class C).
Abiraterone (Includes Zytiga) ↔ Cvd
Moderate Potential Hazard, Moderate plausibility
Applies to: Cardiovascular Disease, Arrhythmias, History - Myocardial Infarction, Hypokalemia, Fluid Retention
Abiraterone may cause hypertension, hypokalemia and fluid retention as a consequence of increased mineralocorticoid levels resulting from CYP17 inhibition. Use caution when treating patients whose underlying medical conditions might be compromised by increases in blood pressure, hypokalemia or fluid retention such as patients with heart failure, recent myocardial infarction, ventricular arrhythmias. Use with caution in patients with cardiovascular disease and monitor regularly.
Zytiga (abiraterone) drug Interactions
There are 643 drug interactions with Zytiga (abiraterone)
Zytiga (abiraterone) alcohol/food Interactions
There is 1 alcohol/food interaction with Zytiga (abiraterone)
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
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