Definition: a chemical reaction between an alkaline solution of meta-dinitrobenzene and an active methylene group (carbon-16) of 17-ketosteroids; it is the basis of the 17-ketogenic steroid assay test; more generally, a reaction between methylene ketones and aromatic polynitro compounds in alkaline solutions.
Synonym(s): Zimmermann test
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Examples: glitazone, GI cocktail, etc.