Definition: In molecular biology, unorthodox pairing between the base at the 5' end of an anticodon and the base that pairs with it (in the 3' position of the codon); thus, the anticodon 3'-UCU-5' may pair with 5'-AGA-3' (normal or Watson-Crick pairing) or with 5'-AGG-3' (wobble). Wobble pairings can occur between the unusual base hypoxanthine and adenine, uracil, or cytosine; between uracil and guanine; and between guanine and uracil, when in the 5' position of an anticodon.
See Also: wobble base
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Examples: glitazone, GI cocktail, etc.