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Medical Term:

wobble

Pronunciation: wah'bel

Definition

In molecular biology, unorthodox pairing between the base at the 5' end of an anticodon and the base that pairs with it (in the 3' position of the codon); thus, the anticodon 3'-UCU-5' may pair with 5'-AGA-3' (normal or Watson-Crick pairing) or with 5'-AGG-3' (wobble). Wobble pairings can occur between the unusual base hypoxanthine and adenine, uracil, or cytosine; between uracil and guanine; and between guanine and uracil, when in the 5' position of an anticodon.

See Also: wobble base

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