the development of a substance-specific syndrome that follows the cessation of, or reduction in, intake of a psychoactive substance that the person previously used regularly; clinical syndrome of disorientation, perceptual disturbance, and psychomotor agitation following the cessation of chronic use of excessive quantities of alcohol is termed alcohol withdrawal syndrome. The syndrome that develops varies according to the psychoactive substance used. Common symptoms include anxiety, restlessness, irritability, insomnia, and impaired attention.
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Examples: glitazone, GI cocktail, etc.