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Wegener granulomatosis

Pronunciation: veg'en-er

Definition: a disease occurring mainly in the fourth and fifth decades that is characterized by necrotizing granulomas, vasculitis, and ulceration of the upper respiratory tract, with purulent rhinorrhea and nasal obstruction, and sometimes with otorrhea, hemoptysis, pulmonary infiltration and cavitation, and fever. Exophthalmos, involvement of the larynx and pharynx, and glomerulonephritis may occur. The underlying condition, a vasculitis affecting small vessels, is possibly caused by an immune disorder. Cases in which only the lungs are involved have been seen; isolated tracheal stenosis is increasingly recognized.

See Also: lymphomatoid granulomatosis

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.