Definition: macroglobulinemia occurring in old people, characterized by proliferation of cells resembling lymphocytes or plasma cells in the bone marrow, anemia, increased sedimentation rate, and hyperglobulinemia with a narrow peak in ?-globulin or ß2-globulin at about 19 S units. The spleen, liver, or lymph nodes are often enlarged with frequent purpura or mucosal bleeding.
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