Pronunciation: vin-blas'ten sul'fat
A dimeric alkaloid obtained from Vinca rosea. It arrests mitosis in metaphase (although vincristine is more active in this respect) and exhibits greater antimetabolic activity than does vincristine; used in the treatment of Hodgkin disease, choriocarcinoma, acute and chronic leukemias, and other neoplastic diseases; blocks microtubule assembly.
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Examples: glitazone, GI cocktail, etc.