A steroid-inducible, evolutionarily conserved, homodimeric secreted protein with many biologic activities including a proinflammatory effect, inhibition of soluble lipoprotein-lipase A2, and chemotaxis of neutrophils and monocytes. It binds to several putative receptors on several cell types and inhibits cellular invasion of the extracellular matrix. It is found in blood and urine, uterus and numerous other tissues, but not kidneys. In mice, uteroglobin has been shown to bind to fibronectin (Fn), preventing Fn self-aggregation and subsequent abnormal tissue deposition, especially in glomeruli. It is essential for maintaining normal renal function in mice.
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Examples: glitazone, GI cocktail, etc.