Definition: an “incomplete” form of antibody that has a single binding site; in the case of Rh+ erythrocytes, such an anti-Rh antibody may coat the cells but not cause them to agglutinate in saline; however, agglutination does occur when such coated cells are suspended in serum or other protein media, such as albumin, therefore called serum agglutinin.
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Examples: glitazone, GI cocktail, etc.