Definition: an enzyme that catalyzes the reversible reaction of l-tyrosine and α-ketoglutarate producing p-hydroxyphenylpyruvate and l-glutamate; this enzyme catalyzes a step in l-phenylalanine and l-tyrosine catabolism; a deficiency of this enzyme is associated with tyrosinemia II.
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Examples: glitazone, GI cocktail, etc.