Definition: an acute infectious disease caused by Salmonella typhi and characterized by a continued fever rising in a steplike curve the first week, severe physical and mental depression, an eruption of rose-colored spots on the chest and abdomen, tympanites, early constipation, diarrhea, and sometimes intestinal hemorrhage or perforation of the bowel; average duration is 4 weeks, although aborted forms and relapses are not uncommon; the lesions are located chiefly in the lymph follicles of the intestines (Peyer patches), the mesenteric glands, and the spleen; antibody titer of the Widal test rises during the infection, and early positive results to blood and urine cultures become negative, usually results in immunity.
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Examples: glitazone, GI cocktail, etc.