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tryptophan 2,3-dioxygenase


Definition: an oxidoreductase catalyzing the reaction of l-tryptophan and O2 to produce l-N-formylkynurenine; an adaptive enzyme, the level (in the liver) being controlled by adrenal hormones; a step in tryptophan catabolism; also, a step in the synthesis of NAD+ from tryptophan.

Synonym(s): pyrrolase, tryptophan oxygenase, tryptophan pyrrolase, tryptophanase1

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© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.