- the triphasic response to the firm stroking of the skin. Phase 1 is the sharply demarcated erythema that follows a momentary blanching of the skin and is the result of release of histamine from the mast cells. Phase 2 is the intense red flare extending beyond the margins of the line of pressure but in the same configuration, and is the result of arteriolar dilation; also called axon flare because it is mediated by axon reflex. Phase 3 is the appearance of a line wheal in the configuration of the original stroking.
- A similar response resulting from an intradermal injection of histamine.
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Examples: glitazone, GI cocktail, etc.