Pronunciation: tri-meth'o-prim sul'fa-meth-oks'a-zol
A drug combination consisting of a dihydrofolate reductase inhibitor (trimethoprim) and a sulfonamide antibacterial drug (sulfamethoxazole). The drug combination is synergistic as the drugs interfere with two successive steps in the formation/utilization of folic acid by microorganisms. Used to treat many infectious diseases.
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Examples: glitazone, GI cocktail, etc.