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transglutaminase

Pronunciation: tranz'glu-ta'min-as

Definition: A group of enzymes that catalyze the calcium-dependent acyl transfer reaction in which the amide moiety of peptide-bound glutaminyl residues serve as acyl donor; a specific transglutaminase covalently cross-links fibrin molecules between glutamine and the e-amino group of a lysyl residue, thus producing a more stable fibrin clot; another transglutaminase participates in the formation of the chemically resistant envelope of the stratum corneum during terminal differentiation of keratinocytes.

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© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.
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