Definition: A group of compounds, included in the eicosanoids, formally based on thromboxane, but with the terminal COOH group present; biochemically related to the prostaglandins and formed from them through a series of steps involving the formation of an endoperoxide (an O–O bridge between carbons 9 and 11 in the prostaglandins) by a cyclooxygenase, followed by a rearrangement (catalyzed by thromboxane synthase) that inserts one of the two oxygen atoms between carbons 11 and 12, leaving the other still bridging carbons 9 and 11. Thromboxanes are so named from their influence on platelet aggregation and the formation of the oxygen-containing six-membered ring (pyran or oxane). Like the prostaglandins, individual thromboxanes (abbreviated TX) are designated by letters (A, B, C, etc.) and subscripts indicating structural features.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.
Search Stedman's Medical Dictionary
Examples: glitazone, GI cocktail, etc.