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Pronunciation: tet'ro-do-tok'sin

Definition: A potent neurotoxin found in the liver and ovaries of the Japanese pufferfish, Sphoeroides rubripes, other species of pufferfish, and some newts; produces axonal blocks of the preganglionic cholinergic fibers and the somatic motor nerves. Tetrodotoxin blocks voltage-gated Na+ channels in excitable tissues.

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.