A clinical neurologic syndrome characterized by muscle twitches, cramps, and carpopedal spasm, and when severe, laryngospasm and seizures; these findings reflect irritability of the central and peripheral nervous systems, usually resulting from low serum levels of ionized calcium or, less commonly, magnesium. Causes include hyperventilation, hypoparathyroidism, rickets, and uremia.
[G. tetanos, tetanus]
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Examples: glitazone, GI cocktail, etc.