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ß-? thalassemia


Definition: thalassemia due to a gene that depresses synthesis of both ß- and ?-globin chains by the chromosome bearing the abnormal gene. Heterozygous state: thalassemia minor with Hb F comprising 5–30% of total hemoglobin but distributed unevenly among cells, Hb A2 reduced or normal. Homozygous state: moderate anemia with only Hb F present, no Hb A or Hb A2.

Synonym(s): F thalassemia

Further information

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.