Definition: thalassemia due to a gene that depresses synthesis of both ß- and ?-globin chains by the chromosome bearing the abnormal gene. Heterozygous state: thalassemia minor with Hb F comprising 5–30% of total hemoglobin but distributed unevenly among cells, Hb A2 reduced or normal. Homozygous state: moderate anemia with only Hb F present, no Hb A or Hb A2.
Synonym(s): F thalassemia
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Examples: glitazone, GI cocktail, etc.