- a second mutation that alters the anticodon in a tRNA so that it can recognize a nonsense (stop) codon, thus suppressing termination of the amino acid chain.
- genetic changes such that the effect of a m. in one place can be masked by a second m. in another location. There are two types: intergenic suppression (occurring in a different gene) and intragenic suppression (occurring in the same gene but at a different site).
Synonym(s): nonsense mutation
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Examples: glitazone, GI cocktail, etc.