Definition: a peptide neurotransmitter composed of eleven amino acyl residues (with the carboxyl group amidated), normally present in minute quantities in the nervous system and intestines of humans and various animals and found in inflamed tissue, that is primarily involved in pain transmission and is one of the most potent compounds affecting smooth muscle (dilation of blood vessels and contraction of intestine) and thus presumed to play a role in inflammation.
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Examples: glitazone, GI cocktail, etc.