stiff person syndrome
Definition: a rare disorder manifested clinically by the continuous isometric contraction of many of the somatic muscles; contractions are usually forceful and painful and most frequently involve the trunk musculature, although limb muscles may be involved. This is an autoimmune disease, with circulating antibodies against the GABA-synthesizing enzyme and glutamic acid decarboxylase, among other types of antibodies present.
Synonym(s): stiff man syndrome
Search Stedman's Medical Dictionary
Examples: glitazone, GI cocktail, etc.