Definition: the velocity of an enzyme-catalyzed reaction in which, over the time course of the study, the concentration of any enzyme species is constant (for an enzyme-substrate binary complex, ES, d[ES]/dt ˜ 0; for this to hold true, the total enzyme concentration must be much less than the initial substrate concentration.
Synonym(s): steady-state rate
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Examples: glitazone, GI cocktail, etc.