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Medical Term:

standard urea clearance


Definition: the value obtained when the square root of the urine flow (when below 2 mL/min) is multiplied by the urine urea concentration and divided by the whole blood urea concentration; represents an old empiric adjustment for the effect of low urine flow on urea excretion; sometimes corrected for body size by dividing by some function of body weight or surface area. Later, plasma concentration was substituted for blood concentration in the calculation. The normal value is about 54 mL per minute per 1.73 m2 in an adult.

Synonym(s): Van Slyke formula

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