A large, vascular lymphatic organ lying in the upper part of the abdominal cavity on the left side, between the stomach and diaphragm, composed of white and red pulp; the white consists of lymphoid nodules and diffuse lymphoid tissue; the red consists of venous sinusoids between which are splenic cords; the stroma of both red and white pulp is composed of reticular fibers and cells. A framework of fibroelastic trabeculae extending from the capsule conveys blood vessels to and from the splenic pulp. The spleen is a blood-forming organ in early life and later a storage organ for red corpuscles and platelets; because of the large number of macrophages present in the spleen it also acts as a blood filter, identifying and destroying effete erythrocytes as well as participating in the immune defense of the body.
Synonym(s): splenTA, lien
Search Stedman's Medical Dictionary
Examples: glitazone, GI cocktail, etc.