Pronunciation: spi'rem, spi'rem
Definition: Term formerly applied to the first stage of mitosis or meiosis (prophase) during which extended chromosome filaments have the appearance of a loose ball of yarn, on the incorrect supposition that the filaments were continuous and later broke apart to form individual chromosomes.
[G. speirema, a coil 1]
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Examples: glitazone, GI cocktail, etc.