Definition: headache, usually frontal or occipital, which follows lumbar puncture; precipitated by patient's sitting or standing, and relieved by lying down; due to leakage of CSF fluid through the puncture site, with resulting reduction in CSF pressure and traction on the dural and cerebral vessels.
Synonym(s): post–lumbar puncture syndrome
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Examples: glitazone, GI cocktail, etc.