- The reaction of a dissolved salt with the solvent to form an acid and a base; the (partial) reverse of neutralization. If the solvent is water, an amphiprotic solvent, solvolysis is called hydrolysis.
- The reaction of the solvent with a solute, resulting in the scission of a bond and incorporation of the atoms of the solvent into the product.
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Examples: glitazone, GI cocktail, etc.