- Any abnormality indicative of disease, discoverable on examination of the patient; an objective indication of disease, in contrast to a symptom, which is a subjective indication of disease.
- An abbreviation or symbol.
- psychology any object or artifact (stimulus) that represents a specific thing or conveys a specific idea to the person who perceives it.
[L. signum, mark]
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Examples: glitazone, GI cocktail, etc.