Definition: that a rabbit injected intradermally with a small quantity of lipopolysaccharide (endotoxin) followed by a second intravenous injection 24 hours later will develop a hemorrhagic and necrotic lesion at the site of the first injection.
Synonym(s): Shwartzman reaction
See Also: generalized Shwartzman phenomenon
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Examples: glitazone, GI cocktail, etc.