Skip to Content
Medical Term:

sex hormone-binding globulin


Definition: a plasma ß-globulin, produced by the liver, which binds testosterone and, with a weaker affinity, estrogen; serum levels of SHBG in women are twice those found in men; serum concentrations are increased in certain types of liver disease and in hyperthyroidism but are decreased with advancing age, by androgens, and in hypothyroidism.

Synonym(s): testosterone-estrogen-binding globulin

© Copyright 2016 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.