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sex hormone-binding globulin


Definition: a plasma ß-globulin, produced by the liver, which binds testosterone and, with a weaker affinity, estrogen; serum levels of SHBG in women are twice those found in men; serum concentrations are increased in certain types of liver disease and in hyperthyroidism but are decreased with advancing age, by androgens, and in hypothyroidism.

Synonym(s): testosterone-estrogen-binding globulin

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.