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secretory component

 

Definition: a polypeptide chain found in external secretions (tears, saliva, colostrum) associated with immunoglobulins A and M. It also may occur in free form but when attached to dimeric IgA, it facilitates transport across the mucosal epithelial surface. The secretory piece is derived by proteolytic cleavage of the immunoglobulin receptor on epithelial cells.

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© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.
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