Pronunciation: shmit tahn'how-zer
Definition: a method for fractionation of nucleic acid, based upon the fact that RNA (but not DNA) is hydrolyzed to nucleotides by alkali; RNA can be hydrolyzed in about 2 hours in 0.75 n NaOH, but 18 hours and 0.3 n NaOH usually are used.
[Gerhard Schmidt, S. J. Thannhauser]
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Examples: glitazone, GI cocktail, etc.