Skip to Content

saccharopine dehydrogenase

 

Definition: two enzymes that are used in the pathway of l-lysine catabolism; the first isoform catalyzes the reversible conversion of l-lysine, a-ketoglutarate, and NADH to saccharopine and NAD+; the other isoform reversibly catalyzes the conversion of saccharopine and NAD+ to l-glutamate, NADH, and l-a-aminoadipate ?-semialdehyde. A deficiency of one of these isoforms is associated with familial hyperlysinemia and saccharopinuria.

Disclaimer: This site is designed to offer information for general educational purposes only. The health information furnished on this site and the interactive responses are not intended to be professional advice and are not intended to replace personal consultation with a qualified physician, pharmacist, or other healthcare professional. You must always seek the advice of a professional for questions related to a disease, disease symptoms, and appropriate therapeutic treatments.
© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.
Hide