Definition: A chronic granulomatous process involving the nose, upper lip, mouth, and upper air passages; starts usually as a growth of hard smooth nodules in the anterior nares that spreads backward into the pharynx, larynx, trachea, and even bronchi; it may involve the external auditory meatus and is caused by a specific bacterium, Klebsiella rhinoscleromatis.
[rhino- + G. skleroma, an induration]
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Examples: glitazone, GI cocktail, etc.