Definition: an acquired encephalopathy of young children that follows an acute febrile illness, usually influenza or varicella infection; characterized by recurrent vomiting, agitation, and lethargy, which may lead to coma with intracranial hypertension; ammonia and serum transaminase levels are elevated; death may result from edema of the brain and resulting cerebral herniation. May be linked to aspirin ingestion.
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