Definition: a conceptual approach allowing the study of gene function; it can be summarized as “from gene to phenotype” as opposed to forward genetics, which can be summarized as “from phenotype to gene.” It uses structural changes in the gene by deletion through gene knockout or disruption by site-directed mutagenesis, and then investigating the effects of such alterations on the phenotype of the cell or organism.
Synonym(s): positional cloning
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